This use case is used most commonly across the following platforms:
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Acquisition campaigns are plagued with overlap with existing customers, wasting budget and reducing effectiveness. Exclude all existing customers from acquisiton campaigns and target new customers only.
Create the audience in your chosen platform
Create new audience in AUDIENCES
In 'Audience settings' choose the audience from step 1 in the 'Audience' dropdown
Schedule the audience
Run the audience
Check the audience has populated in the platform (subject to platform specific timescales)
Your audience will continue to refresh based on the schedule chosen in the audience settings